Authors: Panchali Tarafder, Kaushik Sarkar, Partha P. Nath, Mukti Mondal, Goutam Paul
Abstract: We report here that Bisphenol A (BPA) induces cardiac risk by producing oxidative stress linked ventricular degeneration and altering lipid metabolism. The experiment was carried out on adult rats of Sprague-Dawley strain. BPA (50mg/kgBW/day) was administered for 20 and 30 days. We observed significant increase in serum levels of total cholesterol, triglyceride, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) and decrease in the level of high density lipoprotein (HDL) in BPA treated rats. The activities of antioxidant enzymes- superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were decreased significantly and the production of malondialdehyde (MDA) was increased significantly in BPA exposed rats. Further, we found significant degenerative changes in the histoanatomical structure in heart ventricular myocytes in hematoxylin-eosin stained ventricular tissue sections of rats. From the results it is suggested that BPA induces the cardiac risk by promoting atherosclerosis presumably by increasing the formation of atheromatous lipid; and by inducing oxidative stress linked ventricular degeneration of heart.
Keywords: BPA, ventricular myocytes, oxidative stress, lipid, catabolism