Authors: Dr. Manjeet Kaur Narula, Dr. R.K. Soni
Abstract: Low antioxidant levels and oxidative stress due to airway inflammation are important determination of asthma severity. The aim of the present study was to evaluate level of Vitamin C and Vitamin E in patients with bronchial asthma and to correlate these with the severity of disease. Study included 155 asthmatic cases and 156 healthy subjects. Asthmatic Patients were classified as mild, moderate and severe on the basis of forced expiratory volume in first second percent (FEV1 %). All the subjects were non smoker. A significant decrease in levels of Vitamin C was observed but the decrease in Vitamin E was non significant. According to severity of asthma Vitamin C level decreased in all the groups of patients as compared to controls. However, Vitamin E levels decreased significantly in moderate group only. Low plasma concentration of both Vitamin C and Vitamin E suggests possibility of a physiological interaction between these antioxidants.
Keywords: Asthma, Severity, Vitamin C, Vitamin E