DOI: 10.5176/2345-7821_ACMR14.07

Authors: Raymond Cooper, D. James Morre. and Dorothy M. Morre

Abstract:

The relation between green tea catechins and cell protection through a cell surface protein, ENOX2 (tNOX) has been identified. When the ENOX2 of cells is inhibited, the cells fail to enlarge after division, cease to divide, and after a few days undergo apoptosis. To date, epigallocatechin gallate (EGCg) in green tea is the most effective polyphenol ENOX2 blocker found without any adverse effects on normal cells. Furthermore, in animal studies, the catechin composition comprising of epicatechin (EC), epigallocatechin (ECG) and EGCg is 10-fold more efficacious than EGCg in inhibiting ENOX2, reducing growth of cancer cells in culture and growth of transplanted mouse mammary tumors with the catechins when administered intra-tumorally. Using this same ENOX2 assay, upon the addition of Capsicum powder in a ratio of green tea extract to Capsicum powder of 25:1 gave a 10 fold more efficacious dose. The amount is thus equivalent to administration of a total catechin level of 100 nM. Furthermore the combination of green tea concentrate and powdered Capsicum reduces oxidative stress in both cancer (HeLa) and non-cancer (MCF-10A) cells.

Keywords: Green tea, Cancer prevention, ENOX2 inhibition

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