Authors: Hsi-Jen Chen, Chiu-Hui Dai and Chuan-Yau Chang
Four issues in green chemistry are a search for: (1) alternative feedstocks, (2) green solvents, (3) new synthesis pathways, and (4) inherently safer chemistry. In this paper, we propose a novel synthesis pathway to the production of Carbaryl that avoids hazardous intermediates and hazardous by-products by way of an addition reaction, which is considered as one of the atom-economic reactions. This is accomplished by using α-naphthol, methyl amine, carbon monoxide and oxygen (that is, oxy-carbonylation) as raw materials,
C10 H 7OH CH 3 NH 2 CO 1 O2 C12 H11NO2 H 2O2
This approach appears to be an excellent synthesis route to produce Carbaryl, with only water as by-product. In the research, we also present all possible synthesis pathways of Carbaryl.The thermodynamic constraints in regard to spontaneity as well as atom economy and safety were provided. In order to extend the green chemistry to green engineering, we also propose a conceptual process design scheme for the manufacture of Carbaryl.
Keywords: Green Chemistry; Green Engineering; Atom Economy; Conceptual Process Design; Oxy-carbonylation; Carbaryl