Authors: Mohamed Mustafa Ibrahim, Hapipah Mohd Ali and Mahmood Ameen Abdullah
Tryptamine Schiff bases were prepared by the condensation reaction of ethanolic solution of tryptamine with 5-chlorosalicylaldehyde, 5-nitosalicylaldehyde and 3,5 ditertiarybutyl salicylalehyde. The ligands were coordinated to Zn(II), Cu(II), and Ni(II). All the ligands and complexes prepared have been characterized by spectroscopic methods such as IR spectra, 1H and 13C NMR, UV-Vis, mass spectra, elemental C H N analysis, and magnetic susceptibility measurements, as well as atomic absorption spectroscopy for metal analysis. Spectroscopic data shows that the ligands are bonded to Zn and Cu metal centers via N and O atoms in a distorted tetrahedral geometry, whereas square planar geometry is proposed for Ni complexes.
The biological activities of the ligands and complexes as anti ulcer agents have been investigated using Cimetidine as a standard drug. The screening was done on high and low doses (60mg/kg and 30mg/kg body weight respectively) on Sprague-Dawley rats which had been ulcer-induced by absolute ethanol. The ulcer lesion of the stomachs were identified and counted and then correlations between the effects of the different compound have been made. The results revealed very effective inhibition of gastric ulcer for ligands and complexes.
Keywords: Schiff bases; ligands; transition metal complexes; gastric ulcer