DOI: 10.5176/2345-7821_ACMR13.09

Authors: Lucia Kucerova Svetlana Skolekova and Martin Bohac Jozef Fedeles

Abstract:

Mesenchymal stromal cells (MSCs) are an important component of tumor microenvironment. Understanding the crosstalk between tumors and the network of secreted cytokines and growth factors may lead to importantt new therapeutic approaches in controlling the growth and metastasis of tumors. Adipose tissue (AT) is abundant source of MSCs for therapeutic and regenerative medicine. AT-MSC were described to substantially influence the tumor cells within their vicinity. We have shown that MSCs stimulate epithelial-mesenchymal transition (EMT) in human breast cancer cells SKBR3 in vitro and support mammosphere formation. The EMT is one of the early steps in the invasion-metastasis cascade, therefore we suggested the AT-MSCs can increase tumor cell aggressiveness. We tested several potentially drugable signaling axes in order to counteract these effects. We have found that blocking of VEGF receptors and MEK/ERK signaling pathway in the presence of AT-MSC-secreted factors influenced proliferation of tumor cells. We have shown that AT-MSC express a wide scale of cytokines, chemokines and growth factors, may stimulate or inhabit the proliferation of tumor cells depending on the context. However, the role of AT-MSC in signalling axis of malignant cells remains to be further investigated.

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