DOI: 10.5176/2382-5669_CCMR14.10
Authors: Himmlova Lucie, Prochazkova Jarmila, Podzimek Stepan, Janatova Tatjana, Duskova Jana and Adamkova Vera
Abstract:
The evidence of relationship between oral cavity diseases and cardiovascular diseases is increasing. Therefore, the periodontitis may be a risk factor for inflammatory-degenerative diseases of heart and big vessels. Metal ions released from dental materials may affect not only mucosal system in oral cavity, but may be transferred to other tissues and affect its functions.
Aims: The first aim of this study was to test the presence of periodontal bacterial DNA in the samples of aortic valves extracted during surgery and to assess the concomitant presence of identical periodontal bacterial DNA in periodontal environment of the same patient. The second aim was to perform cardiovascular examination of followed-up patients with oral discomfort due to the metal intolerance.
Material and methods: Fifteen patients with chronic periodontitis, scheduled for the aortic valve replacement surgery were involved in the study. In the pre-operation stage they underwent examination of the oral cavity and samples of periodontal pockets contents were taken, the aortic valves samples were taken during surgery. All samples were processed by molecular technique using the 454 pyrosequencing for the qualitative detection of selected periodontal bacteria. Followed-up patients with diagnosed metal intolerance were recommended to replace their metal materials in oral cavity to nonmetallic ones approximately 10 years ago. During follow-up examination they underwent preventive cardiovascular examination and it was examined if they fulfilled our recommendations and the actual metal intolerance reaction was determined.
Results: The periopathogenic Porphyromonas gingivalis in aortic valves samples as well as in samples from periodontal pockets was found. Eighty-eight percent of followed-up patients with worsened health status still had the intolerated metallic materials in their oral cavities, on the other hand, only 25 {6e6090cdd558c53a8bc18225ef4499fead9160abd3419ad4f137e902b483c465} of followed-up patients with improved health status had the intolerated metallic materials in their oral cavities. The most commonly intolerated metals in followed-up patients with worsened health status were mercury, gold and nickel.
Conclusions: The presence of periopathogenic microflora in aortic valves was proved in this study. The preventive cardiovascular examinations should be performed in patients with oral discomfort due to the metal intolerance.
Keywords: valves; chronic periodontitis; metal intolerance; followed-up patients; 454 pyrosequencing
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