DOI: 10.5176/2382-5685_VETSCI15.31
Authors: Agnieszka Noszczyk-Nowak, Alicja Cepiel, Adrian Janiszewski, Robert Pasławski, Urszula Pasławska and Józef Nicpoń
Abstract:
The aim of the study was to analyze the safety of intracoronary antlerogenic stem cell homogenate and its effects on intracardiac conduction in healthy swine. The study included 12 domestic pigs (Sus domesticus) with baseline body weights of 25-30 kg. Complete blood counts and biochemistry were determined in all the animals, followed by a basic echocardiography and invasive electrophysiology study (EPS) of the heart. All measurements were taken under general anesthesia with intramuscular midazolam (30 mg/m2), intravenous propofol (2 µg/kg/min) and inhalatory isoflurane (2-3vol{6e6090cdd558c53a8bc18225ef4499fead9160abd3419ad4f137e902b483c465}). The swine administered stem cell homogenate and the controls did not differ significantly in terms of their leukocyte counts and C-reactive protein concentrations, left-atrial-to-aortic root diameter ratio, end-diastolic left ventricular internal diameter and fractional shortening (FS). However, there was a tendency to an increase in FS after intracoronary administration of antlerogenic stem cells. No significant intergroup differences were found in the analyzed electrophysiological parameters and types of stimulated arrhythmias. Altogether, these findings confirm the safety of the antlerogenic stem cell homogenate.
Keywords: heart, swine, antlerogenic stem cells
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