DOI: 10.5176/2382-5685_VETSCI15.32
Authors: Agnieszka Noszczyk-Nowak, Alicja Cepiel, Adrian Janiszewski, Robert Pasławski, Urszula Pasławska, Józef Nicpoń
Abstract:
The aim of the study was to analyze the effect on intracoronary antlerogenic stem cell homogenate on electrophysiological parameters of the heart in swine with doxorubicin-induced myocardial injury. The study included 12 domestic pigs (Sus domesticus) with initial body weights of 25-30 kg. Complete blood counts and biochemistry were determined in all the animals, followed by a basic echocardiography and invasive electrophysiology study (EPS) of the heart. All measurements were taken under general anesthesia with intramuscular midazolam (30 mg/m2), intravenous propofol (2 μg/kg/min) and inhalatory isoflurane (2-3vol{6e6090cdd558c53a8bc18225ef4499fead9160abd3419ad4f137e902b483c465}). The results were subjected to statistical analysis with STATISTICA 9.1 PL package. The significance of differences in dependent and independent variables was determined with Wilcoxon signed rank test and Mann-Whitney U-test, respectively. The threshold of statistical significance was set at p≤0.05. No statistically significant differences were found between the electrophysiological parameters of the heart, CSNRT, AH, HV, HRA-LA 150, LA-HRA 150, VERP 150, AERP 150, AVNERP 150, in pigs administered the stem cell homogenate and control animals, both at the baseline and after 3 weeks of follow up.
Keywords: heart, swine, electrophysiology, antlerogenic stem cells
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