ISBN: 978-981-08-8407-9

Authors: Lee Seong Wei, Wendy Wee, Marinah Muhammad

Abstract:

This paper described optimization of cost and dosage of furazolidone in controlling Edwardsiellosis in African catfish (Clarias gariepinus) culture. This study was carried out to determine the minimum cost and
dosage of furazolidone for the maximum survival and growth rate of African catfish infected with Edwardsiella tarda. African fish were treated with furazolidone at dosage of 16, 32, 64 mg/kg of fish for one week
before intraperitoneally infected with Edwardsiella tarda. The infected fish were continually treated with medicated feed for the next three weeks. Survival and daily growth rate of the experimental fish were
recorded at the end of experiment. Optimization of cost and dosage of furazolidone based on survival and daily growth rate of the fish were carried out using response surface methodology. In the
present study, the optimum cost and dosage of furazolidone for 40.2 {6e6090cdd558c53a8bc18225ef4499fead9160abd3419ad4f137e902b483c465} survival rate and 28.5 {6e6090cdd558c53a8bc18225ef4499fead9160abd3419ad4f137e902b483c465} daily growth rate of African catfish were RM 219.8 per kg of fish and 16.6 mg per kg of fish, respectively. Based on cost and effectiveness of furazolidone in controlling Edwardsiellosis in African catfish indicated this antibiotic is not promising as antimicrobial agent as well as growth promoter for aquaculture use.

Keywords: Response surface, optimization, furazolidone, Edwardsiellosis, African catfish, Clarias gariepinus

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