DOI: 10.5176/2251-2489_BioTech40
Authors: Tiijani Adam, U. Hashim, Leow Pei Ling, Chee Pei Song and Foo K.L.
Abstract: Tremendous effort and promising experimental results were established, however, the fundamental mechanism of electrical sensing of bimolecular with viable fluidic delivery system for interaction and the design considerations of NW Sensors remain poorly understood. For Nanowire to reach its potential it must be integrated with sophisticated fluid delivery system for complete diagnosis system in situ, therefore, there a need for PDMS Microfluidics chip to be integrated with Silicon Nanowire to achieve an affordable and reliable Lab on-chip. The study proposed silicon Nano wire biosensor for low concentration of label-free detection Using in-vitro Clinical samples to detect biological species especially cancer cell and other related diseases. Biosensors based on nanotechnology are rapidly developing and are becoming widespread in the biomedical field and analytical chemistry. For these nanobiosensors to reach their potential, they must designed and fabricated with conformity of significant parameters (dimension, material and development processes )on which selectivity and sensitivity of a device are quantified.The research is proposed to develop ultra high sensitive and selective Nano Lab-On-Chip Medical Diagnostic System using integrated Microfluidics and silicon Nanowire based transducer for low concentration and single bio-molecule label-free detection that lead to any related diseases Using in-vitro Clinical samples.
Keywords: Nano Lab on chip, PDMS, Nanotechnology, Biosensor, polysilicon
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