DOI: 10.5176/2345-783X_PHARMA14.47
Authors: Ram Kumar Sahu, Amit Roy, Arvind Kumar Jha
Abstract:
Skin care formulations are used almost regularly and universally in different forms to enhance beauty. The aim of the present was to study the protective effects of herbal cream comprising extracts of Emblica officinalis, Daucus carota and Cucumis sativus against ultraviolet–induced oxidative damage in rats. The plant parts were extracted with 90{6e6090cdd558c53a8bc18225ef4499fead9160abd3419ad4f137e902b483c465} ethanol. The herbal cream was formulated by incorporating the different concentration of various ethanol extracts in cream base. The herbal creams were applied in mice before 4 hours to UV exposure. The protective effect of cream was determined by measuring the biochemical parameters namely catalase, lipid peroxidation and glutathione level. Additionally, histopathological study of mice was performed. The results showed that cream treated mice lessen the impact of UV light-induced photoaging on skin by lowering malondialdehyde level and increasing glutathione and catalase level compared to UV-irradiated mice. During histopathological study, cream treated mice after UV exposure showed no changes in histological characters of skin. This study has confirmed the photo-protective effect of herbal extracts containing creams for skin photoaging.
Keywords: Herbal cream, UV radiation, oxidative damage, photoaging
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