DOI: 10.5176/2251-2489_BioTech13.71
Authors: Sarika Amdekar, Vinod Singh
Abstract:
Our recent study has shown that Lactobacillus scavenged free radical from liver and kidney in an arthritis model. Role of NSAID’s induced organ damage is a well-known fact. In present study we have investigated whether oral administration of Lactobacillus acidophilus to pubertal rats would provide protection against collagen induced arthritis (CIA) associated oxidative stress from testis and ovaries.
Methods: Male and female wistar rats (200 gm weight, 6 weeks old) were included in this study. Induction of arthritis and oral administration of L. acidophilus, indomethacin and vehicle were started on same day. All rats were graded for arthritis score at the end of each week. Oxidative stress markers were evaluated in testis and ovary homogenates. Histopathology of testis and ovary were also done.
Results: L. acidophilus decreased arthritis score (P<0.0001) as well maintained normal histology of testis and ovaries. Oral administration of L. acidophilus decreased oxidative stress parameters from ovaries and testis homogenates (P<0.0001).
Conclusion: Collectively, our data indicate that oral supplementation of L. acidophilus can significantly mitigate arthritis associated oxidative impairments in testis and ovary as well as improved arthritis score. This study suggests its efficacy as selective COX 2 inhibitors in complementary therapy for management of arthritis and associated oxidative stress mediated complications.
Keywords: Oxidative stress, Reproductive organs, Lactobacillus acidophilus, Collagen induced arthritis Cyclooxygenase
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