DOI: 10.5176/978-981-08-8119-1_BioTech2011_33
Authors: Kim, Kwangnyeon, Jungmin Cho, Juhyun Son, Jiyoung Shim and Taeboo Choi
Abstract:
This study was progressed to demonstrate a subchronic toxicity of B9-vitamineral complex in male and female Sprague-Dawley (SD) rats on GLP system. We have studied metabolites which produced by liquid fermentation process, and produced folylpolyglutamate(B9-VitapolTM) which has a wide range of application than folic acid. B9-Vitamineral complex is produced by combining folylpolyglutamate and mineral through liquid soybean fermentation technology. The rats were treated with B9-Vitamineral complex at a dose 500, 1,000 and 2,000 mg/kg/day intragastrically for 13 weeks. To evaluate the safety of B9-Vitamineral complex, we examined the body weight, the feed intake, the clinical signs, the ophthalmological test, the hematological and the serum biochemical analysis. We also observed the histopathological changes of liver and kidney in rats. No death and abnormal clinical signs were observed on feed consumption for 13 weeks. B9-Vitamineral complex. Hematological findings and biochemical examination revealed no significantly different from control group in net body weight gain, food and water consumption, organ weight, orpthalmic findings and urine analysis among the groups treated with different doses of 9-Vitamineral complex. From these results, no observation effect level (NOEL) of B9-vitamineral complex is 2,000 mg/kg/ day under the condition employed in this study.
Keywords: B9-Vitamineral complex, folylplolyglutamate, subchronic, toxicity, rats, food
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