Synthesis of Some-2-thioxo-3-substituted-2,3-dihydro-1H-quinazolin-4-one Derivatives as Potential Antibacterial agents

DOI: 10.5176/2301-3761_CCECP.15

Authors: Monirah A. Al-Alshaikh, Danha S. Al-Shamary, Fatama E.M. El-Baih

Abstract:

New routes for the synthesis of different thioxoquinazolinone derivatives 2a-d via condensation of the anthranilic with aryl isothiocyanate in the presence of absolute ethanol using ultrasound irradiation method. The substituted-4 oxoquinazolin-2-ylthioethylacetate derivatives 3a-d were prepared by S-alkylation of quinazolin-2-thione derivatives 2a-d with ethyl chloro acetate followed by hydrazine hydrate offered the hydrazide derivatives 4a-d. The structures of the synthesized compounds were mainly confirmed on the basis of spectroscopic methods. Moreover, the synthesized compounds were screened for antibacterial activities in vitro.Compounds 2c and 2d exhibited good activity against gram negative bacteria while compounds 2b,3a,3b and 4d displayed good activity against gram positive bacteria.