DOI: 10.5176/2345-783X_PHARMA14.51
Authors: Venkatalakshmi Ranganathan, Yeo Pei Xia, Gooi Mei Seong, Gan Li Ting, Ravi Sheshala
Abstract:
Buccal delivery is considered to be an important alternative to the per oral route for the systemic administration of drugs. The aim of the study was to develop and evaluate mucoadhesive buccal tablets of Metoprolol tartrate for systemic delivery. Metoprolol tartrate mucoadhesive buccal tablets were prepared by direct compression method using ethyl cellulose and mucoadhesive polymers namely, sodium carboxy methyl cellulose and sodium alginate. FTIR and DSC analysis were carried out to investigate the drug polymer interactions. All the formulations were subjected to evaluation of physicochemical parameters such as hardness, thickness, friability, surface pH, swelling index and disintegration time. The mean surface pH of the prepared tablets was found to 6-7 which is favourable for oral mucosa. In-vitro drug release studies demonstrated that Metoprolol tartrate release from the selected tablets followed diffusion kinetics with a maximum drug release and it is confirmed that the tablet has the ability to deliver the drug. The present study indicates enormous potential of erodible mucoadhesive buccal tablet containing Metoprolol tartrate for systemic delivery with an added advantage of circumventing the hepatic first pass metabolism.
Keywords: Buccal delivery, Metoprolol tartrate, buccal tablet, in vitro drug release, First pass metabolism
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