DOI: 10.5176/2345-783X_PHARMA14.07
Authors: Dr. Bhupendra Prajapati
Abstract:
The study is focus to formulate solid formulation of liquid self nanoemulsion (SNE) of Exemestane HCl. Based on the solubility studies, Caprol microexpress as oil phase, Tween 80 as a surfactant and Triacetin as a co-surfactant were used to formulate SNE. It was evaluated for optical clarity, particle size, drug content and viscosity. Screen formulation was taken for vitro cytotoxicity screening and in vivo pharmacokinetic study. Optimized SNE showed particle size (37.65 nm), Polydispersity index (0.835) and Zeta potential (-30.3. The dose response curves demonstrated that it had greater {6e6090cdd558c53a8bc18225ef4499fead9160abd3419ad4f137e902b483c465} cell inhibition as well as greater AUC. After preliminary screening by loading factor, flow characteristics and blend uniformity, tablets were prepared by direct compression using MCC (PH 102), Aerosil 200 as adsorbent and cross povidone as superdisintegrants. Tablets were evaluated for hardness, friability, weight variation, assay, disintegration test, invitro drug release, droplet size, zeta potential, TEM and accelerated stability study. Optimized formulation showed 7-8 minutes of disintegration time and above 80 {6e6090cdd558c53a8bc18225ef4499fead9160abd3419ad4f137e902b483c465} dissolution within 1 hour. Finally, concluded that by converting liquid SNEDDs there no change in effectiveness however it increases stability of formulation and acceptability for patient.
Keywords: Solid self emulsified drug delivery, Bioavialabitliy, Oral Drug Delivery
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