DOI: 10.5176/2345-783X_PHARMA14.30
Authors: Andrei Dondas, Teodora Alexa, Andrei Luca, and Catalina Roxana Bohotin
Abstract:
Methylene blue (MB) has numerous molecular targets, such as nitric oxide, soluble guanylate cyclase and monoamino-oxidase A, all of which may play a role in pain. We studied, in mice, the effects of single and repeated systemic (i.p) administrations of MB on thermonociception, visceral and formalin pain, as well as on locomotor activity. The results demonstrated that 2h after one dose, MB had antinociceptive effects on the hot plate test and visceral pain, and no effect on tail flick test, formalin pain, locomotor activity. Daily administration for 2 weeks did not change the latencies of the thermonociception tests and the locomotor activity when compare with baseline and control group. After the 14th dose we noted an antinociceptive effect of MB not only on the visceral pain, but also on orofacial formalin pain. A reduction of the spontaneously locomotor activity was observed after repeated doses. The results demonstrate that MB has analgesic effects in some murine models of pain and repeated administration of the drug, within a short time period, might improve its analgesic effects.
Keywords: methylene blue, nociception, pain, behaviour, analgesia
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