DOI: 10.5176/2345-783X_PHARMA13.02
Authors: Anthony Tsarbopoulos
Abstract:
The origin of many neurodegenerative disorders like Alzheimer’s Disease (AD) lies in protein processing failures, which leads to protein aggregation and accumulation as amyloid fibrils. The major proteinaceous component found in post mortem analyzed tissues is the beta amyloid (Aβ) peptide. In this paper, we screen the in vitro antiamyloidogenic activity of several components isolated from natural products.
Keywords: Alzheimer’s Disease, beta amyloid peptide, natural products, mass spectrometry, electrospray tandem mass spectrometry
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